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昨シーズンH1N1、及びH5N1予防接種に対する効果等の評価 

昨シーズンの新型H1N1インフルエンザに対する予防接種、及びH5N1インフルエンザの原型ウイルスに対する予防接種の投与回数・投与量・安全性・効果を評価した、WHOの報告。

効果とは、抗体産生で観ているだけなのか?

10歳以上の場合、大多数の予防接種で一回だけの投与で十分。生後6ヶ月から3歳の場合、二回目の投与が必要。3から9歳の場合、予防接種の種類によって、二回目の投与が必要な場合があった、ということのようだ。


以下、引用~~~


Vaccine. 2010 Jul 23. [Epub ahead of print]

Report of the 6th meeting on the evaluation of pandemic influenza vaccines in clinical trials World Health Organization, Geneva, Switzerland, 17-18 February 2010.
Girard MP, Katz J, Pervikov Y, Palkonyay L, Kieny MP.

French National Academy of Medicine, 39 rue Seignemartin, 69008 Lyon, France.

Abstract
On February 17-18, 2010, the World Health Organization (WHO) convened the 6th meeting on the "Evaluation of pandemic influenza vaccines in clinical trials" to review the progress made on new A (H1N1) 2009 vaccines and prototype H5N1 vaccines and their evaluation in clinical trials. A number of vaccine types were reviewed, including classical egg-derived and cell culture-derived inactivated vaccines, such as split virus or whole-virion vaccines, and live-attenuated vaccines (LAIV), as well as vaccines developed using new technologies. The amount of antigen needed, the effect of adjuvants and the number of doses required to induce adequate antibody responses in various populations, together with the issue of safety of the vaccines, were major topics of the meeting. The effectiveness of H1N1 vaccines and the need for standardization of vaccine potency tests were also discussed. Independent of the vaccine type and the presence or absence of an adjuvant, all A (H1N1) 2009 vaccines were well tolerated, eliciting only mild to moderate local or systemic reactions. For most vaccines tested, a single dose was sufficient to elicit a potentially protective antibody response in the majority of vaccines >10 year of age. However, a second dose of vaccine was needed to boost immune responses in infants and toddlers 6 months to 3 years of age and, with some vaccines, in children aged 3-9 years. Copyright © 2010. Published by Elsevier Ltd.. All rights reserved.

PMID: 20659520 [PubMed - as supplied by publisher]

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