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低線量被曝による次世代への遺伝的不安定性の移行 

原爆被爆者の二世にも発がんの頻度が高いことが報告されている。

チェルノブイリで低線量被曝(その程度はこの抄録では不明)を受けた父親から生まれた子供に、遺伝的な不安定性が認められたとする報告。

放射能を侮ってはいけない。次世代にも大きな影響を及ぼす。


以下、引用~~~

Environ Mol Mutagen. 2011 Aug;52(7):538-46.
doi: 10.1002/em.20655. Epub 2011 Apr 28.
Analysis of genomic instability in the offspring
of fathers exposed to low doses of ionizing
radiation.
Aghajanyan A, Kuzmina N, Sipyagyna A, Baleva
L, Suskov I.
SourceDepartment of Molecular Biology and
Cytogenetic, Federal State Institution
"Russian Scientific Center of Roentgeno-Radiology"
of Ministry of Health and Social Development,
Moscow, Russia.
ann-aghajanyan@yandex.ru.

Abstract
Transgenerational genomic instability was studied in
nonirradiated children born from fathers who were
irradiated with low doses of ionizing radiation
while working as clean-up workers at the Chernobyl
Nuclear Power Plant (liquidators) and nonirradiated
mothers from nuclear families. Aberrant cell
frequencies (ACFs), chromosomal type aberration
frequencies, and chromatid break frequencies (CBFs)
in the lymphocytes of fathers-liquidators, and their
children were significantly higher when compared
with the control group (P < 0.05). Individual ACFs,
aberration frequencies, and CBFs were independent
of the time between irradiation of the father and
conception of the child (1 month to 18 years).
Chromosomes were categorized into seven groups
(A through G). Analysis of aberrant chromosomes within
these groups showed no differences in the average
frequency of aberrant chromosomes between children
and fathers-liquidators. However, significant
differences were observed in the average frequency
of aberrant chromosomes in groups A, B, and C
between children and mothers in the families of
liquidators. These results suggest that low doses
of radiation induce genomic instability in fathers.
Moreover, low radiation doses might be responsible
for individual peculiarities in transgenerational
genomic instability in children (as a consequence
of response to primary DNA damage). Thus, genomic
instability may contribute to increased morbidity
over the lifetime of these children.

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